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Am J Med 100(6):611616 Ghimire S, Kyung E, Lee JH, Kim JW, Kang W, Kim E (2013) An evidence-based approach for providing cautionary recommendations to sulfonamide-allergic patients and determining cross-reactivity among sulfonamide-containing medications

Meningococcus primarily utilizes hemoglobin, transferrin, and lactoferrin as a source of iron, via specific outer membrane systems such as HmbR/HupAB for hemoglobin/heme and TbpA/TbpB and LbpA/LbpB for transferrin and lactoferrin, respectively

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Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases